日本の乳糜尿患者における，バンクロフト糸状虫循環抗原，フィラリア抗原特異的IgGならびにIgG4抗体の検出

摘要

Serum sarnples from Japanese chyluria patients were examined for filaria specific antibodies and a circulating filarial antigen in order to know if the symptom was filarial in origin. All the sera were negative for the circulating antigen. Anti-Brugia pahangi antibodies were detected in 6 out of 16 serum samples by ELISA after absorption of the sera with Anisakis and Dirofilaria immitis antigens. One of the positive sera showed a high titer for anti-B. pahangi lgG4, suggesting that Wuchereria bancrofti adults were surviving in the patient in recent years. Detection of antibodies would be helpful for immunodiagnosis of filarial chyluria in Japan, where filarial origin is often determined based simply on the history of residence in the past endemic areas.